Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893094 | 0.86 | MTOR (0.43) | MTORRPTORMLST8PDGFRBPDGFRA | |
| SCHEMBL6892877 | 0.80 | CHEK1 (0.47) | MTORPDGFRBPDGFRAPIK3CAPIM1 | |
| SCHEMBL10251181 | 0.77 | MTOR (0.40) | MTORRPTORMLST8PIK3CACHEK1 | |
| SCHEMBL6892132 | 0.76 | MTOR (0.42) | MTORRPTORMLST8 | |
| SCHEMBL6891861 | 0.75 | MTOR (0.42) | MTORRPTORMLST8PIK3CAHSP90AA1 | |
| SCHEMBL10252627 | 0.75 | MTOR (0.39) | MTORRPTORMLST8PDGFRBPDGFRA | |
| SCHEMBL6893626 | 0.72 | PDGFRB (0.38) | MTORRPTORMLST8PDGFRBPDGFRA | |
| SCHEMBL10251100 | 0.72 | MTOR (0.41) | MTORRPTORMLST8PIK3CA | |
| SCHEMBL6892718 | 0.72 | MTOR (0.51) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL6890546 | 0.71 | PIK3CA (0.38) | MTORRPTORMLST8PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |