Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 0.52 |
| ▸ | PARG | Q86W56 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892255 | 1.00 | GRM2 (0.52) | GRM2PARGCYP3A4SMPD3ALDH1A1 | |
| SCHEMBL6893791 | 1.00 | GRM2 (0.52) | GRM2PARGCYP3A4SMPD3ALDH1A1 | |
| SCHEMBL1502970 | 0.88 | GRM2 (0.50) | GRM2PARGCYP3A4ALDH1A1TSHR | |
| SCHEMBL1503038 | 0.85 | GRM2 (0.61) | GRM2PARGTSHRKMT2A | |
| SCHEMBL1502968 | 0.84 | GRM2 (0.64) | GRM2PARGALDH1A1TSHR | |
| SCHEMBL1502974 | 0.84 | GRM2 (0.64) | GRM2PARGALDH1A1TSHR | |
| SCHEMBL1502926 | 0.84 | GRM2 (0.64) | GRM2PARGALDH1A1TSHR | |
| SCHEMBL6894128 | 0.83 | GRM2 (0.45) | GRM2PARGCYP3A4ALDH1A1TSHR | |
| SCHEMBL6891162 | 0.82 | GRM2 (0.50) | GRM2PARGALDH1A1TSHRKMT2A | |
| SCHEMBL1503012 | 0.81 | GRM2 (0.76) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |