Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.82 |
| ▸ | BACE2 | Q9Y5Z0 | 20/20 | 0.82 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1977448 | 0.90 | BACE1 (1.00) | BACE1BACE2APP | |
| SCHEMBL14726708 | 0.90 | BACE1 (1.00) | BACE1BACE2APP | |
| SCHEMBL6893909 | 0.89 | BACE1 (0.73) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL6889703 | 0.87 | BACE1 (0.68) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL6889705 | 0.86 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL1974062 | 0.84 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1975160 | 0.84 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL13193878 | 0.84 | BACE1 (1.00) | BACE1BACE2APP | |
| SCHEMBL1974028 | 0.81 | BACE1 (1.00) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL1973857 | 0.81 | BACE1 (0.88) | BACE1BACE2APPPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011069934-A1 | 2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |