Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.41 |
| ▸ | CDK8 | P49336 | 4/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.40 |
| ▸ | CCNC | P24863 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234160 | 0.84 | CCNC (0.40) | CRBNDDB1CDK8CDK19CCNC | |
| SCHEMBL7882711 | 0.83 | CRBN (0.40) | CRBNDDB1CDK8CDK19CCNC | |
| SCHEMBL6894488 | 0.81 | CRBN (0.44) | CRBNDDB1CDK8CDK19CCNC | |
| SCHEMBL10234481 | 0.81 | CHEK1 (0.46) | CDK8CDK19CCNC | |
| SCHEMBL6893297 | 0.77 | CRBN (0.39) | CRBNDDB1CDK8CDK19CCNC | |
| SCHEMBL6894450 | 0.76 | CRBN (0.42) | CRBNDDB1CDK8CDK19CCNC | |
| SCHEMBL6894418 | 0.75 | NPC1 (0.36) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL7874628 | 0.74 | KDM4E (0.37) | CRBNDDB1KDM4EMEN1NPC1 | |
| SCHEMBL6894908 | 0.73 | CHEK1 (0.48) | CDK8CDK19CCNCJAK2JAK1 | |
| SCHEMBL10239462 | 0.72 | KDM4E (0.37) | KDM4EMEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, PSEN1 | CRBN 1562/4885DDB1 615/4885CDK8 652/4885 |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | CRBN 2219/4885DDB1 956/4885CDK8 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.