Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894483 | 0.89 | EGFR (0.40) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL6894442 | 0.86 | MTOR (0.39) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL6893491 | 0.84 | EGFR (0.39) | EGFRFGFR2PIK3CAMTORAKT1 | |
| SCHEMBL593759 | 0.82 | EGFR (0.41) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL6895987 | 0.81 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL6891509 | 0.80 | NEK2 (0.42) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL584423 | 0.80 | PIK3CA (0.40) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL10280567 | 0.79 | NPC1 (0.41) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL6896005 | 0.79 | EGFR (0.39) | EGFRFGFR2PIK3CAKDM4ENPC1 | |
| SCHEMBL10239709 | 0.79 | PIK3CA (0.37) | EGFRFGFR2PIK3CAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, PSEN1 | EGFR 4536/4885FGFR2 3710/4885PIK3CA 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.