⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Charcoal, Activated SCHEMBL3215747 | 1.00 | — | — | |
| Charcoal, Activated SCHEMBL7749920 | 1.00 | — | — | |
| Fluoride SCHEMBL7111818 | 0.87 | — | — | |
| Charcoal, Activated SCHEMBL9068640 | 0.87 | — | — | |
| Charcoal, Activated SCHEMBL102042 | 0.82 | — | — | |
| Charcoal, Activated SCHEMBL11114803 | 0.82 | — | — | |
| Charcoal, Activated SCHEMBL1003210 | 0.82 | — | — | |
| Charcoal, Activated SCHEMBL55999 | 0.82 | — | — | |
| Charcoal, Activated SCHEMBL912751 | 0.82 | — | — | |
| SCHEMBL3966144 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830136-B1 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIV HAWAII (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6680311-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | ELI LILLY AND COMPANY | 2004-01-20 | — | — | US | disclosed |
| EP-0869786-B1 | PHARMACEUTICAL COMPOUNDS | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-20020128185-A1 | Pharmaceutical compounds | HAWAII, UNIVERSITY OF | 2002-09-12 | — | — | US | disclosed |
| EP-0792875-B1 | Cryptophycin derivatives and their use as anti-microtubule agents | LILLY CO ELI (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6180679-B1 | PARASITICIDE | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-6143909-A | EPOXIDATION; PRODUCING CRYPTOPHYCIN COMPOUNDS HAVING AN EPOXIDE FUNCTIONALITY | ELI LILLY AND COMPANY (US) | 2000-11-07 | — | — | US | disclosed |
| US-6133457-A | CRYPTOPHYCIN COMPOUNDS HAVING ANTIMICROTUBULE ACTIVITY; ANTIMETABOLITES | ELI LILLY AND COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| US-6013626-A | TO INHIBIT THE PROLIFERATION OF MAMMALIAN CELLS; ANTITUMOR AGENTS | THE UNIVERSITY OF HAWAII (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0957912-A4 | — | — | 1999-12-22 | — | — | EP | disclosed |
| EP-0957912-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5977387-A | Process for preparing pharmaceutical compounds | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0870501-A1 | Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections | ELI LILLY AND COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0861838-A2 | Process and intermediates for preparing cryptophycin compounds | ELI LILLY AND COMPANY (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0861839-A1 | Selective epoxidation process for preparing cryptophycin compounds and intermediates | ELI LILLY AND COMPANY (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1998008506-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0792875-A1 | Cryptophycin derivatives and their use as anti-microtubule agents | ELI LILLY AND COMPANY (US) | 1997-09-03 | — | — | EP | disclosed |