Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224496 | 0.99 | GAA (0.55) | CHRM1GAAKMT2ARAB9AKCNH2 | |
| SCHEMBL2275591 | 0.91 | CHRM1 (0.53) | CHRM1GAAKMT2A | |
| SCHEMBL12803237 | 0.90 | CHRM1 (0.53) | CHRM1GAAKMT2A | |
| SCHEMBL2223955 | 0.89 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL2221937 | 0.89 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL12802941 | 0.89 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL6891025 | 0.89 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL2223684 | 0.89 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL2223892 | 0.88 | CHRM1 (0.59) | CHRM1GAAKMT2AKCNH2 | |
| SCHEMBL12803297 | 0.88 | CHRM1 (0.51) | CHRM1GAAKMT2AKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |