Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328215 | 0.94 | MTOR (0.39) | MTORRPTORMLST8 | |
| SCHEMBL10328374 | 0.91 | MTOR (0.38) | MTORRPTORMLST8 | |
| SCHEMBL6893540 | 0.88 | MTOR (0.43) | MTORRPTORMLST8 | |
| SCHEMBL10328335 | 0.83 | MTOR (0.39) | MTORRPTORMLST8 | |
| SCHEMBL10328363 | 0.82 | MTOR (0.41) | MTORRPTORMLST8 | |
| SCHEMBL1072878 | 0.80 | MTOR (0.50) | MTORRPTORMLST8 | |
| SCHEMBL6892350 | 0.79 | MTOR (0.52) | MTORRPTORMLST8 | |
| SCHEMBL10277447 | 0.79 | MTOR (0.52) | MTORRPTORMLST8 | |
| SCHEMBL10328254 | 0.76 | KDM4E (0.34) | MTORRPTORMLST8 | |
| SCHEMBL1074944 | 0.76 | MTOR (0.50) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-07-12 | — | — | US | disclosed |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178744-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MTOR 1/4885RPTOR 3/4885MLST8 14/4885 |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, PSEN1 | MTOR 1824/4885RPTOR 3265/4885MLST8 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.