SCHEMBL6895416

SCHEMBL6895416

CSc1ncn2cc(C3=C(C(=O)O)N4C(=O)[C@@H](C[C@@H](C)O)[C@H]4C3)sc12

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887569 0.87
SCHEMBL6770670 0.86 KDM4E (0.41) KDM4ELMNA
SCHEMBL6886812 0.80 KDM4E (0.40) KDM4ELMNA
SCHEMBL6773435 0.79 KDM4E (0.43) KDM4ELMNA
SCHEMBL7730099 0.78 ESR1 (0.35) KDM4ELMNA
SCHEMBL6622514 0.77 KDM4E (0.44) KDM4ELMNA
SCHEMBL6886873 0.77 KDM4E (0.44) KDM4ELMNA
SCHEMBL6624707 0.77 KDM4E (0.45) KDM4ELMNA
SCHEMBL6887914 0.76 KDM4E (0.38) KDM4ELMNA
SCHEMBL7632494 0.75 KDM4E (0.41) KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6677331-B2 HAVING SUBSTITUTED IMIDAZO(5,1-B)THIAZOLE GROUP AT 2-POSITION; MICROBIOCIDES AGAINST BETA-LACTAMASE PRODUCING BACTERIA AND RESISTANT PSEUDOMONAS MEIJI SEIKA KAISHA, LTD. (JP) 2004-01-13 US disclosed