Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | SCARB1 | Q8WTV0 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276251 | 0.90 | MAPK14 (0.54) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL1302956 | 0.88 | MAPK14 (0.58) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL13798002 | 0.88 | MAPK14 (0.58) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL689699 | 0.87 | MAPK14 (0.53) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL1303140 | 0.87 | MAPK14 (0.58) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL13798005 | 0.87 | MAPK14 (0.59) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL13359214 | 0.87 | MAPK14 (0.59) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL13986462 | 0.86 | MAPK14 (0.55) | MAPK14LYNMAPK9SCARB1BRAF | |
| SCHEMBL5681346 | 0.86 | MAPK14 (0.51) | MAPK14LYNMAPK9 | |
| SCHEMBL14276184 | 0.86 | MAPK14 (0.51) | MAPK14LYNMAPK9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | disclosed |
| EP-2323980-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |