Cesium

Cesium

SCHEMBL6896175

O=C(O)Cc1cccs1.[Cs]

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.57
HPGD P15428 4/20 0.56
ALDH1A1 P00352 2/20 0.56
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
RAB9A P51151 1/20 0.54
USP2 O75604 1/20 0.54
HSD17B10 Q99714 1/20 0.54
POLB P06746 4/20 0.53
TDP1 Q9NUW8 1/20 0.53
PKM P14618 2/20 0.50
NPC1 O15118 1/20 0.49
KDM4E B2RXH2 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL621289 0.98
Fluoride SCHEMBL27971505 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
SCHEMBL28515022 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
SCHEMBL10484325 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
Benzene SCHEMBL10716512 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
SCHEMBL9285235 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL1372448 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
Methane SCHEMBL7760510 0.96 CYP2C19 (0.57) CYP2C19HPGDALDH1A1MEN1KMT2A
Methyl Alcohol SCHEMBL11407062 0.94 CYP2C19 (0.55) CYP2C19HPGDALDH1A1MEN1KMT2A
SCHEMBL1939485 0.94 CYP2C19 (0.55) CYP2C19HPGDALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629627-B1 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL MYERS SQUIBB CO (US) 2004-05-06 EP disclosed
US-6358928-B1 TREATING RESPIRATORY SYSTEM, RHEUMATIC AND GENETIC DISORDERS ENZYME SYSTEMS PRODUCTS 2002-03-19 US disclosed
US-5756832-A REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL BRISTOL-MYERS SQUIBB CO. (US) 1998-05-26 US disclosed
US-5672599-A DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS BRISTOL-MYERS SQUIBB CO. (US) 1997-09-30 US disclosed
US-5670699-A Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring BRISTOL-MYERS SQUIBB CO. (US) 1997-09-23 US disclosed
US-5627278-A MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION BRISTOL-MYERS SQUIBB CO. (US) 1997-05-06 US disclosed
US-5616775-A ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE BRISTOL-MYERS SQUIBB CO. (US) 1997-04-01 US disclosed
US-5508272-A SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-16 US disclosed
EP-0629627-A2 Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1994-12-21 EP disclosed