Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | SCARB1 | Q8WTV0 | 3/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303496 | 0.89 | MAPK14 (0.37) | MAPK14GSK3AABL1EGFRRAF1 | |
| Hydrochloric Acid SCHEMBL688623 | 0.88 | MAPK14 (0.47) | MAPK14GSK3AABL1EGFRRAF1 | |
| SCHEMBL690048 | 0.86 | MAPK14 (0.46) | MAPK14GSK3AABL1EGFRRAF1 | |
| SCHEMBL690054 | 0.85 | EPHX2 (0.34) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL691275 | 0.83 | MAPK14 (0.40) | MAPK14LYNMAPK9SCARB1 | |
| SCHEMBL689929 | 0.83 | MAPK14 (0.43) | MAPK14GSK3AABL1EGFRRAF1 | |
| SCHEMBL689667 | 0.77 | MAPK14 (0.43) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL1303413 | 0.77 | MAPK14 (0.49) | MAPK14GSK3AABL1EGFRRAF1 | |
| SCHEMBL688989 | 0.77 | MAPK14 (0.42) | MAPK14ABL1EGFRRAF1LYN | |
| SCHEMBL689461 | 0.77 | DHODH (0.35) | MAPK14ABL1EGFRRAF1LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | disclosed |