Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078701 | 0.91 | MRGPRX4 (0.48) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL21653635 | 0.89 | MRGPRX4 (0.48) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL23677886 | 0.89 | MRGPRX4 (0.51) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL21653636 | 0.87 | MRGPRX4 (0.49) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL15223509 | 0.84 | ESR1 (0.51) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL20684324 | 0.82 | MRGPRX4 (0.43) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL12301113 | 0.82 | ESR1 (0.51) | MRGPRX4ALDH1A1ESR1 | |
| SCHEMBL14409236 | 0.81 | HTR2C (0.49) | MRGPRX4ALDH1A1NOTUMKDM4ESLC6A4 | |
| SCHEMBL11963241 | 0.81 | SMN1; SMN2 (0.53) | ALDH1A1KDM4E | |
| SCHEMBL20684326 | 0.81 | MRGPRX4 (0.43) | MRGPRX4NOTUMKDM4ESLC6A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
| WO-2011070131-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | C1S, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-10 | MRGPRX4 1014/4885ALDH1A1 1190/4885NOTUM 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.