Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.63 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14211891 | 1.00 | PDE10A (0.63) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211894 | 0.94 | PDE10A (0.63) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6900743 | 0.85 | PDE10A (0.75) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211888 | 0.83 | PDE10A (0.62) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6899536 | 0.82 | PDE10A (0.81) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211785 | 0.81 | PDE10A (0.70) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL6900532 | 0.81 | PDE10A (0.70) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211834 | 0.79 | PDE10A (0.72) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL14211831 | 0.78 | PDE10A (0.84) | PDE10APDE6DPDE5APDE6APDE6G | |
| SCHEMBL2434724 | 0.77 | PDE10A (1.00) | PDE10APDE6DPDE5APDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |
| WO-2011105628-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-01 | — | — | WO | disclosed |