Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.80 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE6A | P16499 | 1/20 | 0.34 |
| ▸ | PDE6G | P18545 | 1/20 | 0.34 |
| ▸ | PDE6B | P35913 | 1/20 | 0.34 |
| ▸ | PDE6C | P51160 | 1/20 | 0.34 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6898248 | 0.92 | PDE10A (0.93) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14120885 | 0.89 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14120391 | 0.89 | PDE10A (0.94) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14120392 | 0.89 | PDE10A (0.94) | PDE10APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL14119877 | 0.88 | PDE10A (0.93) | PDE10APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL2439201 | 0.88 | PDE10A (0.93) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2439792 | 0.88 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2439789 | 0.88 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2434724 | 0.85 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2445481 | 0.85 | PDE10A (1.00) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539342-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2015-04-15 | — | — | EP | disclosed |
| WO-2011105628-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-01 | — | — | WO | disclosed |