Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 8/20 | 0.37 |
| ▸ | DAO | P14920 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533157 | 0.89 | TYR (0.46) | TYRDAOKDM4EIDH1 | |
| SCHEMBL6707590 | 0.88 | — | — | |
| SCHEMBL6708527 | 0.87 | TYR (0.39) | TYRDAOKDM4EIDH1 | |
| SCHEMBL6506819 | 0.83 | TYR (0.37) | TYRDAOKDM4E | |
| SCHEMBL3279828 | 0.83 | TYR (0.39) | TYRDAOKDM4EIDH1 | |
| SCHEMBL13053752 | 0.83 | TYR (0.39) | TYRDAOKDM4EIDH1 | |
| SCHEMBL7177364 | 0.83 | — | — | |
| SCHEMBL6345629 | 0.82 | TYR (0.38) | TYRDAOKDM4EIDH1 | |
| SCHEMBL6345631 | 0.81 | DAO (0.39) | TYRDAOKDM4EIDH1 | |
| SCHEMBL6702707 | 0.81 | TYR (0.47) | TYRDAOKDM4EIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673780-B2 | SUCH AS 4-(4-(3-HYDROXY-3-METHYL-BUTANE-1-SULFINYLMETHYL)-PHENYLMETHANESULFINYL)-2 -METHYL-BUTAN1-OL FOR TREATING AND PREVENTING CARDIOVASCULAR DISEASES, DYSLIPIDEMIAS, DYSPROTEINEMIAS, AND GLUCOSE METABOLISM DISORDERS | ESPERION THERAPEUTICS, INC. | 2004-01-06 | — | — | US | claimed |
| EP-1366024-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002030882-A2 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2002-04-18 | — | — | WO | disclosed |