Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 6/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665472 | 0.82 | CHRM1 (0.54) | CHRM1KDM4ECNR1CNR2TP53 | |
| SCHEMBL11895855 | 0.72 | CHRM1 (0.60) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11895707 | 0.72 | CHRM1 (0.58) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL10314673 | 0.71 | CHRM1 (0.57) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11894926 | 0.71 | CHRM1 (0.54) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11895232 | 0.70 | CHRM1 (0.58) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11895833 | 0.70 | CHRM1 (0.55) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11895623 | 0.70 | CHRM1 (0.70) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11955110 | 0.70 | CHRM1 (0.50) | CHRM1CNR1CNR2PDE4APDE4B | |
| SCHEMBL11895310 | 0.69 | CHRM1 (0.56) | CHRM1KDM4ECNR2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041143-A1 | HETEROCYCLIC-FUSED PYRAZOLO[4,3-c]PYRIDIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-07 | — | — | WO | disclosed |