Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056046 | 0.96 | ESR1 (0.51) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6901788 | 0.86 | ESR1 (0.51) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6898885 | 0.86 | ESR1 (0.53) | ESR1ESR2MCHR1PPARGPPARD | |
| SCHEMBL8502849 | 0.85 | ESR1 (0.64) | ESR1ESR2KCNH2PPARGHTR2B | |
| SCHEMBL6900049 | 0.84 | ESR1 (0.55) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6901973 | 0.84 | ESR1 (0.55) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6895259 | 0.84 | ESR1 (0.57) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6902084 | 0.84 | ESR1 (0.59) | ESR1ESR2PPARGPPARDHTR2B | |
| SCHEMBL6895957 | 0.81 | ESR1 (0.62) | ESR1ESR2HTR2BTMEM97SIGMAR1 | |
| SCHEMBL8343538 | 0.81 | ESR1 (0.68) | ESR1ESR2KCNH2PPARGHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465619-A1 | SUPPRESSION OF CARTILAGE DEGRADATION VIA THE ESTROGEN RECEPTOR | Nordic Bioscience A/S (DK) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003063859-A1 | SUPPRESSION OF CARTILAGE DEGRADATION VIA THE ESTROGEN RECEPTOR | NORDIC BIOSCIENCE A/S (DK) | 2003-08-07 | — | — | WO | disclosed |
| US-6043269-A | ESTROGEN AGONISTS | NOVO NORDISK A/S (DK) | 2000-03-28 | — | — | US | disclosed |
| EP-0937058-A1 | NOVEL $i(CIS)-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998018773-A1 | NOVEL CIS-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-05-07 | — | — | WO | disclosed |