Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901274 | 1.00 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6615969 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6615964 | 0.85 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6783821 | 0.83 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6783824 | 0.83 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6784607 | 0.82 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6784602 | 0.82 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL2848864 | 0.77 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2845641 | 0.75 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL2841711 | 0.74 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787555-B2 | SUCH AS 4-(4-FLUOROPHENYL)-5-(2-PHENYLMETHYLAMINO)PYRIMIDIN-4-YL)-1-ETHOXYMETHYL -(1,2,3)TRIAZOLE FOR INHIBITION OF RELEASE OF INFLAMMATORY INTERLEUKINS; FOR TREATMENT OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, AND CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY | 2004-09-07 | — | — | US | disclosed |