Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064384 | 0.86 | PDE4B (0.47) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| SCHEMBL8353076 | 0.86 | PDE4B (0.47) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| SCHEMBL8349772 | 0.85 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PDE4C | |
| SCHEMBL6063464 | 0.85 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PDE4C | |
| SCHEMBL6063322 | 0.81 | PDE4B (0.47) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL6063423 | 0.80 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| SCHEMBL6063109 | 0.80 | PDE4B (0.50) | PDE4BPDE4APDE4DCYP3A4PDE4C | |
| SCHEMBL6063303 | 0.78 | PDE4B (0.53) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| SCHEMBL8353996 | 0.78 | PDE4B (0.53) | PDE4BPDE4APDE4DCYP3A4CYP2C9 | |
| SCHEMBL6062787 | 0.77 | PDE4B (0.49) | PDE4BPDE4APDE4DCYP3A4PDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476158-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068235-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |