Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172080 | 0.87 | MAPT (0.50) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6899190 | 0.85 | KDM4E (0.52) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6903967 | 0.84 | MAPT (0.51) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6901796 | 0.83 | MAPT (0.49) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6898972 | 0.75 | KDM4E (0.57) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6901805 | 0.73 | KDM4E (0.60) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6903392 | 0.72 | MAPT (0.56) | MAPTLMNAHTTGAASRC | |
| SCHEMBL6905188 | 0.71 | MAPT (0.54) | MAPTLMNAHTTGAASRC | |
| SCHEMBL21387007 | 0.71 | KCNA3 (0.55) | MAPTHTTGAAKMT2AKDM4E | |
| SCHEMBL6905179 | 0.69 | MAPT (0.56) | MAPTLMNAHTTGAASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767916-B2 | 1-(4-METHYL-7-(3-METHYLBUT-2-ENYLOXY)COUMARIN-8-YL)-3-(PYRIDIN E-3-YL)- PROPEN-1-ONE FOR EXAMPLE; ANTIPROLIFERATIVE AGENT; TUMOR, CANCER TREATMENT | INDENA S.P.A. (IT) | 2004-07-27 | — | — | US | disclosed |