Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 9/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14827143 | 0.86 | COMT (0.66) | COMT | |
| SCHEMBL2465251 | 0.84 | COMT (1.00) | COMT | |
| SCHEMBL6900252 | 0.77 | COMT (0.64) | COMT | |
| SCHEMBL6900999 | 0.77 | COMT (0.63) | COMT | |
| SCHEMBL14827138 | 0.77 | COMT (0.60) | COMT | |
| SCHEMBL23249865 | 0.75 | DYRK1A (0.44) | COMT | |
| SCHEMBL6901910 | 0.75 | COMT (0.67) | COMT | |
| SCHEMBL6900222 | 0.75 | COMT (0.64) | COMT | |
| SCHEMBL14827201 | 0.75 | COMT (0.77) | COMT | |
| SCHEMBL19331190 | 0.73 | COMT (0.66) | COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109254-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |