SCHEMBL6902273

SCHEMBL6902273

NC(=O)OCc1ccccc1C(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.61
MAOB P27338 4/20 0.60
MAOA P21397 1/20 0.52
POLQ O75417 1/20 0.44
FFAR4 Q5NUL3 2/20 0.43
FFAR1 O14842 1/20 0.43
GRIN2B Q13224 1/20 0.43
TACR1 P25103 1/20 0.42
TGM2 P21980 1/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
NR3C2 P08235 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
SCD O00767 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5932728 0.84 IDO1 (0.58) IDO1MAOBMAOAPOLQFFAR4
SCHEMBL28208721 0.83 MAOB (0.42) IDO1MAOBMAOAKDM4EALDH1A1
SCHEMBL14446886 0.83 MAOB (0.60) IDO1MAOBMAOAPOLQFFAR4
SCHEMBL5933478 0.83 IDO1 (0.56) IDO1MAOBMAOAPOLQFFAR4
SCHEMBL27719473 0.81 IDO1 (0.54) IDO1MAOBMAOAPOLQTGM2
SCHEMBL19765223 0.81 MAOB (0.55) IDO1MAOBMAOAPOLQFFAR4
SCHEMBL29501710 0.81 SMN1; SMN2 (0.48) IDO1MAOBKDM4EALDH1A1PPARG
SCHEMBL20724253 0.80 MAOB (0.54) IDO1MAOBMAOAPOLQFFAR4
SCHEMBL27849087 0.79 MAOB (0.39) IDO1MAOBMAOAKDM4EALDH1A1
SCHEMBL24901098 0.79 MAOB (0.52) IDO1MAOBMAOAPOLQFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105263924-B Cxcr7 receptor modulators 爱杜西亚制药有限公司 2018-10-19 CN disclosed
CN-105263924-A Cxcr7 receptor modulators ACTELION PHARMACEUTICALS LTD 2016-01-20 CN disclosed
WO-2011060321-A1 TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF CHDI, INC. (US) 2011-05-19 WO disclosed