Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659958 | 0.86 | SMN1; SMN2 (0.38) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1660633 | 0.72 | SLC6A4 (0.40) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1661852 | 0.70 | PDE4B (0.41) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1662618 | 0.70 | SMN1; SMN2 (0.34) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1658631 | 0.70 | SMN1; SMN2 (0.39) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL14727761 | 0.66 | SCN9A (0.32) | METALDH1A1HPGDKDM4E | |
| SCHEMBL6603014 | 0.65 | ATM (0.49) | MAPTSMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL10681289 | 0.63 | MEN1 (0.54) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9877851 | 0.60 | SMN1; SMN2 (0.49) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL21986617 | 0.60 | SMN1; SMN2 (0.45) | MEN1KMT2AMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |