Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.68 |
| ▸ | MMEL1 | Q495T6 | 6/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768279 | 1.00 | MME (0.68) | MMEMMEL1RORCPTPN1PPARG | |
| SCHEMBL3776089 | 1.00 | MME (0.68) | MMEMMEL1RORCPTPN1PPARG | |
| SCHEMBL1768281 | 1.00 | MME (0.68) | MMEMMEL1RORCPTPN1PPARG | |
| SCHEMBL1768280 | 0.89 | MME (0.62) | MMEMMEL1PTPN1PPARAMEN1 | |
| SCHEMBL1793637 | 0.89 | MME (0.62) | MMEMMEL1PTPN1PPARAMEN1 | |
| SCHEMBL1768282 | 0.89 | MME (0.62) | MMEMMEL1PTPN1PPARAMEN1 | |
| SCHEMBL3701727 | 0.85 | MME (0.54) | MMEMMEL1ACEGPR34 | |
| SCHEMBL3701729 | 0.85 | MME (0.54) | MMEMMEL1ACEGPR34 | |
| SCHEMBL16602086 | 0.84 | MME (0.64) | MMEMMEL1RORCMEN1MAPT | |
| SCHEMBL15608113 | 0.82 | MME (0.54) | MMEMMEL1PPARGPPARAACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011061271-A1 | SUBSTITUTED CARBAMOYLMETHYLAMINO ACETIC ACID DERIVATIVES AS NOVEL NEP INHIBITORS | NOVARTIS AG (CH) | 2011-05-26 | — | — | WO | disclosed |