Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 12/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689850 | 1.00 | MAPK14 (0.43) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL688678 | 1.00 | MAPK14 (0.43) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL1301321 | 1.00 | MAPK14 (0.43) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL690341 | 1.00 | MAPK14 (0.43) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL689109 | 0.93 | MAPK14 (0.43) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL690544 | 0.91 | MAPK14 (0.45) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL1302805 | 0.91 | MAPK14 (0.45) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL689789 | 0.90 | MAPK14 (0.44) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL695463 | 0.90 | MAPK14 (0.44) | MAPK14LYNMAPK9BRAFABL1 | |
| SCHEMBL12103083 | 0.89 | MAPK14 (0.46) | MAPK14LYNMAPK9BRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |