Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14404284 | 0.87 | CFTR (0.36) | MEN1ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL690766 | 0.79 | GSK3A (0.36) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10233040 | 0.79 | MAPT (0.39) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL689550 | 0.78 | POLB (0.34) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL690103 | 0.76 | POLB (0.44) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL15371211 | 0.75 | MEN1 (0.36) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL18873696 | 0.75 | BRAF (0.42) | MEN1ALDH1A1MAPTKMT2APOLB | |
| Hydrochloric Acid SCHEMBL11874645 | 0.74 | POLB (0.48) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL12809304 | 0.74 | MEN1 (0.32) | MEN1ALDH1A1GAAMAPTPKM | |
| SCHEMBL690694 | 0.73 | MEN1 (0.31) | MEN1ALDH1A1GAAMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |
| WO-2017108736-A1 | N-[3-(3-{4-[[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY]-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL} -UREIDO)-PHENYL]-METHANESULFONAMIDE DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-06-29 | — | — | WO | disclosed |