Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9351092 | 0.85 | HIF1A (0.42) | HIF1AHTTALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL30721146 | 0.82 | SNCA (0.51) | HIF1AHTTALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8015170 | 0.82 | SNCA (0.51) | HIF1AHTTALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL26696535 | 0.81 | HIF1A (0.64) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL7929116 | 0.81 | HIF1A (0.38) | HIF1A | |
| Bromide SCHEMBL2768948 | 0.80 | HIF1A (0.52) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2767870 | 0.77 | HIF1A (0.64) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL16191225 | 0.75 | HTT (0.51) | HTTKDM1ADAOFFAR1 | |
| SCHEMBL31526396 | 0.75 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL8030729 | 0.73 | SNCA (0.50) | HIF1AHTTALDH1A1CYP2D6SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149885-B1 | Cyclohexane derivatives, liquid crystal compositions comprising the same and liquid crystal display devices | CHISSO CORP (JP) | 2004-09-22 | — | — | EP | disclosed |
| US-6500503-B2 | Liquid crystal compound containing fluoro substituted benzene ring | CHISSO CORPORATION (JP) | 2002-12-31 | — | — | US | disclosed |
| US-20020066888-A1 | Cyclohexane derivatives, liquid crystal compositions comprising the same and liquid crystal display devices | JNC PETROCHEMICAL CORPORATION (JP) | 2002-06-06 | — | — | US | disclosed |
| EP-1149885-A1 | Cyclohexane derivatives, liquid crystal compositions comprising the same and liquid crystal display devices | CHISSO CORPORATION (JP) | 2001-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020066888-A1 | Cyclohexane derivatives, liquid crystal compositions comprising the same and liquid crystal display devices | SCO2, KLK1, HCN2 | CHRM5 201/4885CHRM1 34/4885CHRM3 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.