Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 15/20 | 0.75 |
| ▸ | PDE8A | O60658 | 3/20 | 0.63 |
| ▸ | MET | P08581 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909177 | 0.90 | PDE8B (0.72) | PDE8BPDE8AADORA3ADORA2AADORA2B | |
| SCHEMBL6909462 | 0.86 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910946 | 0.86 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910951 | 0.86 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910848 | 0.82 | PDE8B (0.77) | PDE8BPDE8AADORA3ADORA2AALDH1A1 | |
| SCHEMBL6910849 | 0.82 | PDE8B (0.77) | PDE8BPDE8AADORA3ADORA2AALDH1A1 | |
| SCHEMBL6910646 | 0.80 | PDE8B (0.69) | PDE8BPDE8AALDH1A1LMNA | |
| SCHEMBL6910920 | 0.80 | PDE8B (0.77) | PDE8BPDE8A | |
| SCHEMBL6910554 | 0.80 | PDE8B (0.71) | PDE8BPDE8A | |
| SCHEMBL6909895 | 0.79 | PDE8B (0.77) | PDE8BPDE8AADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |