Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | USP19 | O94966 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167030 | 0.89 | HDAC6 (0.47) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL1613324 | 0.82 | HDAC6 (0.48) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4378142 | 0.82 | HDAC6 (0.48) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL4373074 | 0.82 | HDAC6 (0.48) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL5912648 | 0.79 | ENPP1 (0.43) | MAPK1ENPP1 | |
| SCHEMBL4377668 | 0.76 | HDAC6 (0.45) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL1614040 | 0.76 | HDAC6 (0.45) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL664005 | 0.76 | HDAC6 (0.55) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4380760 | 0.74 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 | |
| SCHEMBL4380759 | 0.74 | HDAC6 (0.51) | HDAC6TNFHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446124-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | AstraZeneca AB (SE) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003039551-A1 | COMBINATION THERAPY COMPRISING ZD6474 AND A TAXANE | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |
| EP-1244647-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001032651-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2001-05-10 | — | — | WO | disclosed |