Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 20/20 | 0.59 |
| ▸ | PDE8A | O60658 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909132 | 0.82 | PDE8B (0.56) | PDE8BPDE8A | |
| SCHEMBL6911266 | 0.77 | PDE8B (0.72) | PDE8BPDE8A | |
| SCHEMBL6909224 | 0.75 | PDE8B (0.72) | PDE8BPDE8A | |
| SCHEMBL6910452 | 0.75 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6909245 | 0.75 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910356 | 0.75 | PDE8B (0.71) | PDE8BPDE8A | |
| SCHEMBL17545207 | 0.75 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6911014 | 0.75 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910855 | 0.74 | PDE8B (0.68) | PDE8BPDE8A | |
| SCHEMBL6909035 | 0.71 | PDE8B (0.71) | PDE8BPDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |