Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 6/20 | 0.31 |
| ▸ | MAPKAP1 | Q9BPZ7 | 6/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345731 | 0.91 | MTOR (0.34) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL2344690 | 0.81 | ACKR3 (0.36) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL6844722 | 0.78 | MTOR (0.37) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL1288612 | 0.75 | GRM5 (0.34) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL1288653 | 0.75 | GRM5 (0.34) | GRM5 | |
| SCHEMBL15235208 | 0.75 | MTOR (0.36) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL2340763 | 0.75 | PLK1 (0.33) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL2336483 | 0.74 | MTOR (0.34) | MTORRICTORMAPKAP1MLST8PIK3CA | |
| SCHEMBL2049170 | 0.74 | PLK2 (0.49) | PLK2PLK1 | |
| SCHEMBL2049166 | 0.74 | PLK2 (0.49) | PLK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |