Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1508785 | 0.84 | ESR1 (0.47) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL1508701 | 0.84 | ESR1 (0.47) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL11353373 | 0.80 | TTR (0.44) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL11353377 | 0.80 | TTR (0.44) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL23201588 | 0.80 | TTR (0.46) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL4514544 | 0.78 | ESR1 (0.57) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL8375820 | 0.78 | POLB (0.56) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL30235603 | 0.78 | ESR1 (0.57) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL8375818 | 0.78 | POLB (0.56) | ESR1IDO1TDO2TTRDPP4 | |
| SCHEMBL13678677 | 0.78 | ESR1 (0.57) | ESR1IDO1TDO2TTRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |