Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904569 | 0.90 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6821145 | 0.86 | MAPK13 (0.60) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6905834 | 0.85 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6817801 | 0.85 | MAPK1 (0.48) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6817802 | 0.85 | MAPK1 (0.48) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6905240 | 0.84 | MAPK14 (0.68) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6396132 | 0.83 | MAPK14 (0.70) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL6906823 | 0.82 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6395887 | 0.82 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7195744 | 0.80 | MAPK13 (0.56) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202957-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6555710-B1 | Derivatives of 2,2,2-trifluoro-N-2-(benzoylphenylaminophenyl acetamide; antiinflammatory agents, suppression of interleukin (IL)-beta and tumor necrosis factor (TNF)-alpha; antiarthritic, anticholinergic agents; asthma; antiallergens | LEO PHARMACEUTICAL PRODUCTS LTD A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 2003-04-29 | — | — | US | disclosed |