Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11895949 | 0.69 | CHRM1 (0.56) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11955250 | 0.68 | CHRM1 (0.60) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11895557 | 0.65 | CHRM1 (0.54) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11955202 | 0.64 | PDE4A (0.51) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11895443 | 0.63 | CHRM1 (0.63) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6913179 | 0.63 | CHRM1 (0.58) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11973928 | 0.62 | CHRM1 (0.56) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11895329 | 0.61 | CNR2 (0.55) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11894861 | 0.61 | PDE4A (0.54) | CHRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11895126 | 0.60 | CHRM1 (0.54) | CHRM1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011049731-A1 | QUINOLINONE-PYRAZOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-28 | — | — | WO | disclosed |