SCHEMBL691353

SCHEMBL691353

C=CC(=O)OCCC[Si](C)(C)Cl

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.59
ALDH1A1 P00352 4/20 0.59
CYP3A4 P08684 2/20 0.59
HPGD P15428 1/20 0.58
TP53 P04637 3/20 0.48
HIF1A Q16665 3/20 0.48
HSD17B10 Q99714 1/20 0.48
THRB P10828 2/20 0.41
ATM Q13315 1/20 0.38
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HCAR2 Q8TDS4 3/20 0.34
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15477579 0.95 TSHR (0.62) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23322250 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23322097 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23322030 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23321986 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23321803 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23321537 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23321794 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23322183 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL23321525 0.93 TSHR (0.66) TSHRALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240409563-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME GELEST, INC. 2024-12-12 US claimed
EP-4448536-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME GELEST, INC. (US) 2024-10-23 EP claimed
CN-118401532-A High-purity polysiloxane macromer and preparation method thereof 盖列斯特有限公司 2024-07-26 CN claimed
WO-2023113779-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME GELEST, INC. (US) 2023-06-22 WO claimed
US-20230183273-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME GELEST, INC. 2023-06-15 US claimed
US-11597789-B2 Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides WATERS TECHNOLOGIES CORPORATION (US) 2023-03-07 US claimed
CN-110817889-B Preparation method of toughened silica aerogel, toughened silica aerogel and application of toughened silica aerogel 上海中南建筑材料有限公司 2021-07-20 CN claimed
US-10835644-B2 Surface-modified metal and method for modifying metal surface SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2020-11-17 US claimed
CN-110817889-A Preparation method of toughened silica aerogel, toughened silica aerogel and application of toughened silica aerogel 福建六树网络科技有限公司 2020-02-21 CN claimed
US-10251980-B2 Surface-modified metal and method for modifying metal surface SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2019-04-09 US claimed
WO-2003093785-A2 BIOCHIPS WITH SURFACES COATED WITH POLYSACCHARIDE BASED HYDROGELS CIPHERGEN BIOSYSTEMS, INC. (US) 2003-11-13 WO claimed
WO-2003079402-A2 LATEX BASED ADSORBENT CHIP CIPHERGEN BIOSYSTEMS, INC. (US) 2003-09-25 WO claimed
US-20030124371-A1 Hydrophobic surface chip CIPHERGEN BIOSYSTEMS, INC. 2003-07-03 US claimed
WO-2003040700-A1 HYDROPHOBIC SURFACE CHIP CIPHERGEN BIOSYSTEMS, INC. (US) 2003-05-15 WO claimed
EP-0791635-B1 Preapplied silicone threadlocker and sealant LOCTITE CORP (US) 2003-05-02 EP claimed
US-20030032043-A1 Latex based adsorbent chip CIPHERGEN BIOSYSTEMS, INC. 2003-02-13 US claimed
US-20030017464-A1 Latex based adsorbent chip CIPHERGEN BIOSYSTEMS, INC. 2003-01-23 US claimed
EP-0593297-B1 Resin composition for coating and paint HITACHI CHEMICAL CO LTD (JP) 1997-04-16 EP claimed
US-5539051-A ACRYLATE RESIN AND ADDITION TYPE RESIN WITH PENDANT SILICON CONTAINING GROUPS, FOR CONCRETE, MASONRY, NONSTAINING HITACHI CHEMICAL COMPANY CO., LTD. (JP) 1996-07-23 US claimed
EP-0593297-A1 Resin composition for coating and paint HITACHI CHEMICAL CO., LTD. (JP) 1994-04-20 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240409563-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME SSRP1, RPLP2, RPLP1 TSHR 1897/4885ALDH1A1 837/4885CYP3A4 1562/4885
US-20230183273-A1 HIGH PURITY POLYSILOXANE MACROMERS AND METHOD FOR MAKING THE SAME SSRP1, RPLP2, RPLP1 TSHR 1897/4885ALDH1A1 837/4885CYP3A4 1562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.