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Sugi Predict / Compounds / SCHEMBL6914197

SCHEMBL6914197

SCHEMBL6914197

C=C(O)CC1(O)CN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ NR1H2 P55055 2/20 0.39
▸ HPGD P15428 1/20 0.35
▸ EPHX2 P34913 1/20 0.35
▸ GPR119 Q8TDV5 1/20 0.34
▸ RORC P51449 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ CTSK P43235 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ DDB1 Q16531 1/20 0.33
▸ CRBN Q96SW2 1/20 0.33
▸ EPHX1 P07099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23150890 0.87 USP2 (0.40) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL570830 0.87 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL21590786 0.86 USP2 (0.39) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL12331225 0.84 NR1H2 (0.40) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL571404 0.83 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL18696436 0.83 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL21590671 0.83 USP2 (0.37) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL16340420 0.83 NR1H2 (0.46) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL31735249 0.82 NR1H2 (0.38) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL20826636 0.81 USP2 (0.40) USP2SMN1; SMN2NR1H2HPGDEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3150617-A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS Achaogen, Inc. (US) 2017-04-05 — — EP disclosed
EP-2217610-B1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN INC (US) 2016-11-02 — — EP disclosed
WO-2011044501-A9 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2012-04-19 — — WO disclosed
WO-2011044503-A9 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2012-02-09 — — WO disclosed
WO-2011044498-A9 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2012-02-09 — — WO disclosed
WO-2010132760-A9 ANTIBACTERIAL DERIVATIVES OF TOBRAMYCIN ACHAOGEN, INC. (US) 2011-11-03 — — WO disclosed
WO-2010132765-A9 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2011-10-13 — — WO disclosed
WO-2010132839-A9 AMINOGLYCOSIDE DOSING REGIMENS ACHAOGEN, INC. (US) 2011-09-15 — — WO disclosed
WO-2010147836-A9 COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS ACHAOGEN, INC. (US) 2011-09-15 — — WO disclosed
WO-2010132759-A9 ANTIBACTERIAL DERIVATIVES OF DIBEKACIN ACHAOGEN, INC. (US) 2011-09-09 — — WO disclosed
WO-2011044503-A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2011-04-14 — — WO disclosed
WO-2010147836-A1 COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS ACHAOGEN, INC. (US) 2010-12-23 — — WO disclosed
WO-2010132839-A2 AMINOGLYCOSIDE DOSING REGIMENS ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010132759-A1 ANTIBACTERIAL DERIVATIVES OF DIBEKACIN ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010132760-A1 ANTIBACTERIAL DERIVATIVES OF TOBRAMYCIN ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010132777-A2 TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010132765-A2 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010132757-A2 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2010-11-18 — — WO disclosed
WO-2010042850-A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2010-04-15 — — WO disclosed
WO-2009067692-A1 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2009-05-28 — — WO disclosed