Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385064 | 0.91 | PDE10A (0.64) | PDE10AALDH1A1 | |
| SCHEMBL2384493 | 0.90 | PDE10A (0.71) | PDE10AALDH1A1MAPTRXFP1 | |
| SCHEMBL2386639 | 0.89 | PDE10A (0.61) | PDE10AALDH1A1MAPTRXFP1 | |
| SCHEMBL2387135 | 0.89 | PDE10A (0.61) | PDE10A | |
| SCHEMBL2400200 | 0.87 | PDE10A (0.67) | PDE10A | |
| SCHEMBL6915916 | 0.85 | PDE10A (0.76) | PDE10A | |
| SCHEMBL2397245 | 0.85 | PDE10A (0.66) | PDE10AALDH1A1 | |
| SCHEMBL12316438 | 0.84 | PDE10A (0.74) | PDE10A | |
| SCHEMBL2372512 | 0.83 | PDE10A (0.71) | PDE10A | |
| SCHEMBL12266633 | 0.83 | PDE10A (0.74) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |