Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.69 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385506 | 0.92 | PDE10A (0.69) | PDE10ATP53POLBMAPTTHRB | |
| SCHEMBL2397480 | 0.92 | PDE10A (0.68) | PDE10AATRTP53POLBMAPT | |
| SCHEMBL2373814 | 0.91 | PDE10A (0.81) | PDE10AATR | |
| SCHEMBL2397596 | 0.89 | PDE10A (0.64) | PDE10AATRTP53POLBMAPT | |
| SCHEMBL2385774 | 0.89 | PDE10A (0.69) | PDE10ATP53 | |
| SCHEMBL2386118 | 0.89 | PDE10A (0.63) | PDE10AATRTP53POLBMAPT | |
| SCHEMBL15780206 | 0.86 | PDE10A (0.71) | PDE10ATP53POLBMAPTTHRB | |
| SCHEMBL2397273 | 0.86 | PDE10A (0.68) | PDE10ATP53POLBMAPTTHRB | |
| SCHEMBL2385720 | 0.86 | PDE10A (0.63) | PDE10ATP53POLBMAPTTHRB | |
| SCHEMBL2385384 | 0.85 | PDE10A (0.81) | PDE10ATP53POLBMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |