Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 19/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817257 | 0.87 | CXCR2 (0.43) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817510 | 0.83 | CXCR2 (0.56) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6917264 | 0.81 | CXCR2 (0.48) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6917268 | 0.81 | CXCR2 (0.48) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL7614982 | 0.78 | CXCR2 (0.46) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6550790 | 0.77 | CXCR2 (0.67) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817381 | 0.75 | CXCR1 (0.44) | CXCR2CXCR1 | |
| SCHEMBL6817254 | 0.67 | CXCR2 (0.49) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817256 | 0.67 | CXCR2 (0.49) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817506 | 0.63 | CXCR2 (0.70) | CXCR2CXCR1ADRB3TSPOSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191934-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0929302-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-31 | — | — | EP | disclosed |
| EP-1191934-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076516-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0929302-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |