⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1606853 | 0.95 | NPSR1 (0.50) | — | |
| SCHEMBL20740435 | 0.93 | NPSR1 (0.48) | — | |
| SCHEMBL1604408 | 0.93 | NPSR1 (0.48) | — | |
| SCHEMBL9008361 | 0.90 | — | — | |
| SCHEMBL24780851 | 0.79 | CYP3A4 (0.41) | — | |
| SCHEMBL20335470 | 0.79 | NPSR1 (0.36) | — | |
| SCHEMBL990527 | 0.77 | — | — | |
| SCHEMBL311023 | 0.75 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL10835391 | 0.75 | CYP4F2 (0.32) | — | |
| SCHEMBL230256 | 0.74 | NPSR1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111909077-A | 2- (1-bromocyclobutyl) pyridine and synthesis method thereof | 南通大学 | 2020-11-10 | — | — | CN | claimed |
| CN-115960077-B | Preparation method of apamide | 山东新时代药业有限公司 | 2025-11-07 | — | — | CN | disclosed |
| EP-4630412-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS | NMD Pharma A/S (DK) | 2025-10-15 | — | — | EP | disclosed |
| WO-2025067298-A1 | COMPOUND AS GLUTAMINE CYCLASE INHIBITOR | 先声药业有限公司 | 2025-04-03 | — | — | WO | disclosed |
| WO-2024121130-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS | NMD PHARMA A/S (DK) | 2024-06-13 | — | — | WO | disclosed |
| WO-2024121130-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS | NMD PHARMA A/S (DK) | 2024-06-13 | — | — | WO | disclosed |
| CN-114573485-B | Method for synthesizing alkynyl alkyl sulfide | 华南理工大学 | 2023-11-10 | — | — | CN | disclosed |
| CN-115960077-A | Preparation method of apaluamide | 山东新时代药业有限公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-115960077-A | Preparation method of apaluamide | 山东新时代药业有限公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-114573485-A | Method for synthesizing alkynyl alkyl thioether | 华南理工大学 | 2022-06-03 | — | — | CN | disclosed |
| EP-2235017-B1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2011-09-14 | — | — | EP | disclosed |
| CN-101903388-A | Spiroindolinone derivatives as anticancer agents | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| WO-2010121995-A1 | 3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100273819-A1 | 3,3'-Spiroindolinone Derivatives | CHEN LI | 2010-10-28 | — | — | US | disclosed |
| EP-2235017-A1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| US-7776875-B2 | such as 2'S,3S,4'R)-6-chloro-4'-{5-chloro-2-[1-methyl-1-(1-methyl-piperidin-4-ylcarbamoyl)-ethoxy]-phenyl}-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione, used as antiproliferative agents, especially, as anticarcinogenic agents | HOFFMAN-LA ROCHE INC. (US) | 2010-08-17 | — | — | US | disclosed |
| WO-2009080488-A1 | SPIROINDOLINONE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| US-20090163512-A1 | such as 2'S,3S,4'R)-6-chloro-4'-{5-chloro-2-[1-methyl-1-(1-methyl-piperidin-4-ylcarbamoyl)-ethoxy]-phenyl}-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione, used as antiproliferative agents, especially, as anticarcinogenic agents | CHEN LI | 2009-06-25 | — | — | US | disclosed |
| US-7495007-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20080009486-A1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-01-10 | — | — | US | disclosed |