Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762265 | 0.77 | GAA (0.46) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL18904130 | 0.75 | GAA (0.44) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL21650382 | 0.73 | GAA (0.43) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL50204 | 0.73 | GAA (0.61) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL13457835 | 0.72 | GAA (0.46) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL10310296 | 0.72 | GAA (0.50) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL19766578 | 0.71 | GAA (0.42) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL6495036 | 0.71 | GAA (0.46) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL18903854 | 0.70 | GAA (0.44) | GAAKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL12156243 | 0.69 | GAA (0.56) | GAAKDM4ELMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |