Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 18/20 | 0.73 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.73 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19713723 | 0.91 | PTGER4 (0.85) | PTGER4PTGER2 | |
| SCHEMBL1284715 | 0.91 | PTGER4 (0.85) | PTGER4PTGER2 | |
| SCHEMBL692072 | 0.90 | PTGER4 (0.71) | PTGER4PTGER2MAPK8 | |
| SCHEMBL692029 | 0.89 | PTGER4 (0.69) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL30114753 | 0.87 | PTGER4 (0.82) | PTGER4PTGER2 | |
| SCHEMBL691802 | 0.87 | PTGER4 (0.82) | PTGER4PTGER2 | |
| SCHEMBL691905 | 0.87 | PTGER4 (0.77) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL692450 | 0.85 | PTGER4 (0.68) | PTGER4PTGER2MAPK8 | |
| SCHEMBL692240 | 0.85 | PTGER4 (0.72) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL5362840 | 0.85 | PTGER4 (0.67) | PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422779-A1 | SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2012-02-29 | — | — | EP | claimed |
| EP-3431085-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | AskAt Inc. (JP) | 2019-01-23 | — | — | EP | disclosed |
| EP-2965756-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2422779-A1 | SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2012-02-29 | — | — | EP | disclosed |