⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691702 | 1.00 | — | — | |
| SCHEMBL9979034 | 1.00 | — | — | |
| SCHEMBL26978248 | 0.76 | TSHR (0.38) | — | |
| SCHEMBL1678713 | 0.76 | — | — | |
| SCHEMBL4489455 | 0.73 | — | — | |
| SCHEMBL7948575 | 0.71 | — | — | |
| SCHEMBL1678670 | 0.69 | — | — | |
| SCHEMBL8591247 | 0.69 | — | — | |
| Hydrogen Sulfide SCHEMBL28198805 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL28200882 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614336-B2 | Process for preparing N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine derivative | SCI PHARMTECH, INC. (TW) | 2013-12-24 | — | — | US | claimed |
| US-8420832-B2 | Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol | SCI PHARMTECH, INC. (TW) | 2013-04-16 | — | — | US | claimed |
| US-20120190869-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2012-07-26 | — | — | US | claimed |
| US-8168805-B2 | Optically active methylhydroxylaminopropanol compound and its use as intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol | SCI PHARMTECH, INC (TW) | 2012-05-01 | — | — | US | claimed |
| US-8148549-B2 | Preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl) propylamine using optically active methylhydroxylaminopropanol compound as an intermediate | SCI PHARMTECH, INC. (TW) | 2012-04-03 | — | — | US | claimed |
| EP-2228372-B1 | Process for Preparing (S)-(+)-N-Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl-Propylamine by using Optically Active Methylhydroxylaminopropanol Compound as an Intermediate | SCI PHARMATECH INC (TW) | 2012-02-29 | — | — | EP | claimed |
| US-20100234619-A1 | PREPARATION OF (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL) PROPYLAMINE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AS AN INTERMEDIATE | SCI PHARMTECH, INC. (TW) | 2010-09-16 | — | — | US | claimed |
| US-20100234620-A1 | PROCESS FOR PREPARING N-METHYL-N-HYDROXYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE DERIVATIVE | SCI PHARMTECH, INC. (TW) | 2010-09-16 | — | — | US | claimed |
| EP-2228372-A1 | Process for Preparing (S)-(+)-N-Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl-Propylamine by using Optically Active Methylhydroxylaminopropanol Compound as an Intermediate | SCI Pharmatech, Inc. (TW) | 2010-09-15 | — | — | EP | claimed |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | claimed |
| US-8957227-B2 | Preparation of Duloxetine® hydrochloride using optically active methylhydroxylaminopropanol compound as an intermediate | SCI PHARMTECH, INC. (TW) | 2015-02-17 | — | — | US | disclosed |
| US-20140005414-A1 | PREPARATION OF DULOXETINE HYDROCHLORIDE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS AN INTERMEDIATE | SCI PHARMTECH, INC. (TW) | 2014-01-02 | — | — | US | disclosed |
| US-8614336-B2 | Process for preparing N-methyl-N-hydroxyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine derivative | SCI PHARMTECH, INC. (TW) | 2013-12-24 | — | — | US | disclosed |
| US-8530674-B2 | Process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by using optically active methylhydroxylaminopropanol compound as intermediate | SCI PHARMTECH, INC. (TW) | 2013-09-10 | — | — | US | disclosed |
| US-8420832-B2 | Optically active methylhydroxylaminopropanol derivative and its use as intermediate for preparation of (S)-(-)-3-methylamino-1-(-2-thienyl)propan-1-ol | SCI PHARMTECH, INC. (TW) | 2013-04-16 | — | — | US | disclosed |
| US-20100234619-A1 | PREPARATION OF (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL) PROPYLAMINE USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AS AN INTERMEDIATE | SCI PHARMTECH, INC. (TW) | 2010-09-16 | — | — | US | disclosed |
| EP-2228372-A1 | Process for Preparing (S)-(+)-N-Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl-Propylamine by using Optically Active Methylhydroxylaminopropanol Compound as an Intermediate | SCI Pharmatech, Inc. (TW) | 2010-09-15 | — | — | EP | disclosed |
| EP-2228372-A1 | Process for Preparing (S)-(+)-N-Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl-Propylamine by using Optically Active Methylhydroxylaminopropanol Compound as an Intermediate | SCI Pharmatech, Inc. (TW) | 2010-09-15 | — | — | EP | disclosed |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090112001-A1 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(2-THIENYL)PROPAN-1-OL | SCI PHARMTECH, INC. (TW) | 2009-04-30 | — | — | US | disclosed |