Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 10/20 | 0.77 |
| ▸ | F11 | P03951 | 4/20 | 0.77 |
| ▸ | F7 | P08709 | 4/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15291870 | 0.93 | F9 (0.87) | F9F11F7CYP2C9F10 | |
| SCHEMBL1233112 | 0.87 | F9 (1.00) | F9F11F7CYP2C9F10 | |
| SCHEMBL9607613 | 0.87 | F9 (0.81) | F9F11F7CYP2C9F10 | |
| SCHEMBL6919856 | 0.85 | F9 (0.58) | F9F11F7CYP2C9F10 | |
| SCHEMBL6918455 | 0.83 | F9 (0.58) | F9F11F7CYP2C9F10 | |
| SCHEMBL6919134 | 0.81 | F9 (0.68) | F9F11F7CYP2C9F10 | |
| SCHEMBL9607626 | 0.79 | F9 (0.69) | F9F11F7CYP2C9F10 | |
| SCHEMBL15291874 | 0.79 | F9 (0.65) | F9F11F7CYP2C9F10 | |
| SCHEMBL1231106 | 0.79 | F9 (0.76) | F9F11F7CYP2C9F10 | |
| SCHEMBL9607624 | 0.76 | F9 (0.68) | F9F11F7CYP2C9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462123-B1 | 4,5,6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2011017296-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2011-02-10 | — | — | WO | disclosed |