Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919092 | 0.77 | GRM5 (0.55) | GRM5RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL6918338 | 0.75 | GRM5 (0.78) | GRM5RAB9AGAAKDM4ELMNA | |
| SCHEMBL6919206 | 0.72 | GRM5 (0.59) | GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL12411963 | 0.71 | GRM5 (0.60) | GRM5CSF1RLMNA | |
| SCHEMBL12412759 | 0.70 | GRM5 (0.77) | GRM5RAB9ACSF1RGAAPOLB | |
| SCHEMBL12830299 | 0.70 | GRM5 (0.59) | GRM5CSF1RCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL12412756 | 0.70 | GRM5 (0.66) | GRM5CSF1R | |
| SCHEMBL6918563 | 0.70 | GRM5 (0.57) | GRM5 | |
| SCHEMBL12412757 | 0.68 | GRM5 (0.79) | GRM5CSF1RCYP11B1CYP11B2 | |
| SCHEMBL12411975 | 0.68 | GRM5 (0.64) | GRM5CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035209-A1 | SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSTIY (US) | 2011-03-24 | — | — | WO | disclosed |