Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594846 | 0.78 | HTT (0.61) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL6920143 | 0.78 | HTT (0.61) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL5594969 | 0.71 | HTT (0.65) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL5594682 | 0.70 | HTT (0.67) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL6825931 | 0.69 | HTT (0.76) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL5595083 | 0.69 | HTT (0.76) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL4139764 | 0.69 | HTT (0.53) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL27517285 | 0.68 | CA1 (0.32) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL7488566 | 0.68 | HTT (0.62) | HTTALDH1A1CXCR1NPC1RAB9A | |
| SCHEMBL6823585 | 0.67 | CXCR1 (0.55) | HTTCXCR1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |