Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 9/20 | 0.50 |
| ▸ | NOTCH3 | Q9UM47 | 8/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.49 |
| ▸ | NOTCH2 | Q04721 | 1/20 | 0.49 |
| ▸ | NOTCH4 | Q99466 | 1/20 | 0.49 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 2/20 | 0.49 |
| ▸ | CCKAR | P32238 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413314 | 0.89 | SCN9A (0.60) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4994502 | 0.88 | PSEN1 (0.56) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4990936 | 0.87 | PSEN1 (0.59) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4991338 | 0.85 | PSEN1 (0.57) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4989282 | 0.85 | PSEN1 (0.65) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4995284 | 0.85 | PSEN1 (0.53) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4990141 | 0.84 | PSEN1 (0.56) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4991013 | 0.84 | NOTCH1 (0.53) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4993346 | 0.84 | PSEN1 (0.59) | NOTCH1NOTCH3PSEN1PSEN2APH1B | |
| SCHEMBL4412662 | 0.83 | NOTCH1 (0.59) | NOTCH1NOTCH3NOTCH2NOTCH4RBPJ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093372-A4 | CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1093372-A1 | CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-1999066934-A1 | CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |