Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926709 | 0.81 | DYRK1A (0.68) | DYRK1ABRD4KDM4EHSD17B10MAPT | |
| SCHEMBL5830904 | 0.81 | DYRK1A (0.68) | DYRK1ABRD4KDM4EHSD17B10BUB1 | |
| SCHEMBL6695622 | 0.78 | GFER (0.63) | DYRK1AKDM4EL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL1657531 | 0.74 | DYRK1A (0.58) | DYRK1AKDM4EL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL23537356 | 0.73 | PARP1 (0.59) | DYRK1ABRD4KDM4EL3MBTL1HSD17B10 | |
| SCHEMBL4727564 | 0.73 | TAAR1 (0.62) | DYRK1ATAAR1DAOKDM4EL3MBTL1 | |
| SCHEMBL31027151 | 0.73 | DYRK1A (0.58) | DYRK1AKDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL2220752 | 0.73 | DYRK1A (0.58) | DYRK1AKDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL29824193 | 0.73 | PARP1 (0.59) | DYRK1ABRD4KDM4EL3MBTL1HSD17B10 | |
| SCHEMBL4730000 | 0.72 | TAAR1 (0.60) | DYRK1ATAAR1KDM4EL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |