Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 15/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 9/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.42 |
| ▸ | F12 | P00748 | 7/20 | 0.42 |
| ▸ | F7 | P08709 | 7/20 | 0.42 |
| ▸ | CFD | P00746 | 4/20 | 0.41 |
| ▸ | F9 | P00740 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919764 | 0.93 | F2 (0.47) | F2CYP3A4F10PRSS1PRSS2 | |
| SCHEMBL6921206 | 0.91 | F2 (0.49) | F2CYP3A4F10PRSS1PRSS2 | |
| SCHEMBL6922190 | 0.88 | CYP3A4 (0.61) | F2CYP3A4F10PRSS1PRSS3 | |
| SCHEMBL6920944 | 0.87 | F2 (0.50) | F2CYP3A4F10PRSS1PRSS2 | |
| SCHEMBL6919688 | 0.87 | F2 (0.52) | F2CYP3A4F10PRSS1PRSS3 | |
| SCHEMBL6920939 | 0.87 | F2 (0.50) | F2CYP3A4F10PRSS1PRSS2 | |
| SCHEMBL6919204 | 0.86 | F2 (0.48) | F2CYP3A4F10PRSS1PRSS3 | |
| SCHEMBL6919213 | 0.86 | F2 (0.48) | F2CYP3A4F10PRSS1PRSS3 | |
| SCHEMBL6078258 | 0.86 | F2 (0.57) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6922167 | 0.85 | F2 (0.52) | F2CYP3A4F10PRSS1PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004032834-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004032834-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |